Novolog/NovoRapid is a recombinant insulin analog created by substituting proline with aspartic acid at position B28, which prevents hexamer formation and enhances its absorption rate.

Administration & Formulations

Available in:

• 100 U/mL multi-dose vials

• PenFill cartridges

• Prefilled pens (FlexPen, FlexTouch)
  It should be injected 5–10 minutes before meals, into the abdomen, thigh, upper arm, or buttocks. Dosing is individualized based on blood sugar levels, meals, physical activity, and other health factors

Clinical Use

Indicated to improve glycemic control in type 1 and type 2 diabetes, typically as part of a basal-bolus regimen alongside long-acting insulin

Advantages

• Improved postprandial glucose control vs regular insulin due to faster onset.

• Comparable efficacy to insulin lispro (Humalog), with similar potency and safety, though slightly lower risk of late hypoglycemia

  
  

Summary

Novolog/NovoRapid (insulin aspart) is a cornerstone rapid-acting insulin for mealtime glycemic control in diabetes. It offers faster action and precise post-meal glucose management compared to regular insulin. Safely used in multiple delivery formats, it can slightly reduce the risk of delayed hypoglycemia. However, like all insulin, it necessitates diligent glucose monitoring, proper dosing, injection site rotation, and attentive storage. If you'd like comparisons with Fiasp, dosing schedules, or tips for pump use, I'm happy to dive deeper!